Correlation Analysis of Serum RVE1,VCAM-1 Expression Levels and Thyroid Function in Hashimoto Thyroiditis Patients
Objective To investigate the correlation between serum resolvin E1 (RVE1) and vascular cell adhesion molecule-1 (VCAM-1) expression and thyroid function in Hashimoto thyroiditis (HT) patients. Methods A total of 89 HT patients admitted to Lishui District Hospital of Traditional Chinese Medicine in Nanjing from May 2021 to February 2023 were retrospectively analyzed and recorded as the observation group. The medical records of 45 healthy individuals with normal thyroid function during the same period were retrospectively analyzed and recorded as the control group. The expression levels of serum RVE1,VCAM-1,and thyroid function indexes were compared between the observation group and the control group,and the correlation was analyzed. Results The serum RVE1 level in the observation group was lower than in the control group(P<0.05),while the serum VCAM-1 level in the observation group was higher than in the control group (P<0.05). The thyroid peroxidase antibody (TPOAb),thyroid-stimulating hormone (TSH),and anti-thyro-globulin antibody (TgAb) levels in the observation group were higher than those in the control group (P<0.05),whereas free triiodothyronine (FT3) and free thyroxine (FT4) levels were lower (P<0.05). Serum RVE1 expression level was negatively correlated with serum TgAb,TSH,and TPOAb levels (P<0.05) and positively correlated with FT3 and FT4 levels (P<0.05). The expression level of VCAM-1 was negatively correlated with FT3 and FT4 levels (P<0.05) and positively correlated with TgAb,TSH,and TPOAb levels (P<0.05). Conclusion The expression levels of serum RVE1 and VCAM-1 in HT patients were closely related to thyroid function.
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