The Distribution of Pathogenic Bacteria and the Diagnostic Value of Serum MIP-2 and CD40L Levels in Patients with Coronary Heart Disease Complicated with Pulmonary Infection
Objective To investigate the distribution of pathogenic bacteria and the diagnostic value of serum macro-phage inflammatory protein-2 (MIP-2) and CD40 ligand (CD40L) levels in patients with coronary heart disease complicated with pulmonary infection. Methods A total of 93 patients with coronary heart disease complicated with pulmonary infection treated in our hospital from November 2022 to February 2024 (study group) and 93 patients with coronary heart disease without pulmo-nary infection (control group) were selected for the study. Pearson analysis was applied to analyze the correlation between serum MIP-2 and CD40L in the study group. Logistic regression analysis was used to analyze the influencing factors of pulmonary in-fection in patients with coronary heart disease. ROC curve analysis was performed to evaluate the diagnostic value of serum MIP-2 and CD40L levels in patients with coronary heart disease complicated by pulmonary infection. Results 61 strains (59.80％) of Gram-negative bacteria,33 strains (32.35％) of Gram-positive bacteria,and 8 strains (7.85％) of fungi were isolated through pathogen cultivation. There were statistically significant differences in cardiac function grading,LVEF,CPR,PCT,NT-proBNP,MIP-2,and CD40L between the study group and the control group (P<0.05). Serum MIP-2 and CD40L levels in the study group were positively correlated (r=0.362,P=0.000). MIP-2 and CD40L were independent risk factors for pulmo-nary infection in patients with coronary heart disease (P<0.05). The AUC of serum MIP-2,CD40L,and their combination in diagnosing coronary heart disease with pulmonary infection was 0.812 (95％CI=0.750-0.874),0.793 (95％CI=0.729-0.856),and 0.869 (95％CI=0.817-0.921),respectively. The diagnostic value of their combination was significantly higher than individual diagnosis (Z combination-MIP-2=2.191,P=0.028,Z combination-CD40L=2.838,P=0.005). Conclusion Patients with coronary heart disease com-plicated with pulmonary infection are primarily infected with Klebsiella pneumoniae. Elevated levels of serum MIP-2 and CD40L increase the risk of pulmonary infection in these patients. The combination of the two markers provides a higher diagnostic value for coronary heart disease patients with pulmonary infection.
Coronary heart diseasePulmonary infectionDistribution of pathogenic bacteriaMacrophage inflammatory protein-2CD40 ligandDiagnostic value
万方数据
维普
