Relationship Between Serum S100A12,Hcy and ACE2 and Prognosis of Severe Acute Pancreatitis
Objective To investigate the value of serum S100 calcium-binding protein A12 (S100A12),homocysteine (Hcy) and angiotensin-converting enzyme 2 (ACE2) in the prognostic assessment of severe acute pancreatitis (SAP). Methods A total of 118 patients with acute pancreatitis (AP) treated from 2022 to 2023 were studied,divided into SAP group (n=72) and non-SAP group (n=46). Serum S100A12,Hcy,ACE2,and disease severity scores were collected and analyzed for their cor-relations with disease severity and prognosis. Logistic regression was applied to identify risk factors for poor prognosis in SAP patients,and receiver operating characteristic (ROC) curves were used to evaluate the predictive values of serum markers. Re-sults Pearson correlation analysis revealed positive correlations between S100A12 and Hcy levels,and APACHE Ⅱ,Ranson,and BISAP scores (P<0.05),while ACE2 levels showed negative correlations with these scores (P<0.05). Logistic regression analysis identified early shock,S100A12,Hcy,and APACHE Ⅱ score as independent risk factors for poor prognosis in SAP patients,while ACE2 was a protective factor (P<0.05). Serum S100A12 and Hcy levels were positively correlated with poor prognosis (r=0.442,P<0.001),while ACE2 levels were negatively correlated (r=-0.419,P<0.001). ROC curve analysis showed that the predictive ef-ficacies for poor prognosis in SAP patients were 0.728 for S100A12,0.746 for Hcy,and 0.747 for ACE2,respec-tively. Conclusion Serum S100A12,Hcy,and ACE2 are closely related to the severity and prognosis of SAP patients,and their combination provides valuable predic-tive insights for SAP prognosis.
Severe acute pancreatitisS100 calcium-binding protein A12HomocysteineAngiotensin-converting enzyme 2Prognosis assessment
万方数据
维普
