The Evaluation Value of NT-proBNP,Hcy Combined with BPV on Pregnancy Outcomes in Pre-eclampsia Pregnant Women
Objective To evaluate the value of amino-terminal pro-brain natriuretic peptide (NT-proBNP) and homo-cysteine (Hcy) combined with blood pressure variability (BPV) in predicting adverse pregnancy outcomes in pregnant women with preeclampsia (PE). Methods A total of 203 PE pregnant women admitted to Zhongshan Xiaolan People's Hospital from October 2020 to October 2023 were included and divided into good outcome group (129 cases) and poor outcome group (74 cases) based on perinatal outcomes. Clinical characteristics,NT-proBNP,Hcy levels,and BPV (including SBPV and DBPV) were compared between groups. Logistic regression analysis was performed to identify risk factors,and receiver operating characteristic (ROC) curves were used to evaluate the predictive value of NT-proBNP,Hcy,and BPV for adverse pregnancy outcomes. Results The platelet count was higher in the good outcome group than in the poor outcome group,while NT-proBNP and Hcy levels were lower (P<0.05). SBPV and DBPV values were significantly lower in the good outcome group (P<0.05). Logistic regression analysis identified,NT-proBNP,Hcy,SBPV,and DBPV as independent risk factors for adverse outcomes in PE pregnant women (P<0.05). Platelet count is a pro-tective factor for adverse pregnancy outcomes in women with PE. ROC analysis showed that the AUCs of NT-proBNP,Hcy,SBPV,and DBPV in predicting adverse pregnancy outcomes were 0.719,0.851,0.864,and 0.923,respectively. Combined prediction using all three markers yielded the highest AUC of 0.962,with a sensitivity of 97.3％ and a specificity of 94.6％. Conclusion Elevated NT-proBNP and Hcy levels and increased BPV are significant risk factors for adverse pregnancy outcomes in PE pregnant women. Combining NT-proBNP,Hcy,and BPV provides excellent predictive value for adverse perinatal outcomes in this population.
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维普
