Predictive Value of ROX-HR Index Combined with Plasma BNP Level in Fluid Resuscitation of Septic Shock
Objective To investigate the predictive value of ROX-HR index combined with plasma brain natriuret-ic peptide (BNP) level in fluid resuscitation of septic shock. Methods A total of 135 patients with septic shock admitted to Yangzhou University Affiliated Hospital from January 2023 to January 2024 were selected. All patients received fluid resuscita-tion therapy. ROX-HR index and plasma BNP levels were detected before treatment,and the patients were divided into failure group (53 cases) and success group (82 cases) according to the efficacy. Multivariate Logistic regression analysis was performed to identify the factors affecting the efficacy of fluid resuscitation in septic shock patients. The value of receiver operating charac-teristic (ROC) curve analysis of ROX-HR index and BNP in predicting the efficacy of fluid resuscitation therapy was evaluated. Results The ROX-HR index in the failure group was lower than that in the success group (P<0.05),while the serum BNP level was higher than that in the success group (P<0.05). High BNP levels,high SOFA scores,and elevated blood lactate were iden-tified as risk factors for fluid resuscitation failure in septic shock patients (P<0.05),whereas an elevated ROX-HR index was identified as a protective factor (P<0.05). The area under the curve (AUC) for predicting fluid resuscitation failure was 0.794 for the ROX-HR index and 0.759 for BNP. The combined prediction model showed an AUC of 0.970,which was significantly higher than the AUCs of individual predictors (P<0.05). Conclusion Decreased ROX-HR index and elevated plasma BNP levels were associated with fluid resuscitation failure in septic shock patients. The combination of ROX-HR index and BNP levels ef-fectively predict the efficacy of fluid resuscitation therapy.
万方数据
维普
