Analysis of Clinical Efficacy of Inhaled Nitric Oxide in Infants with Acute Bronchiolitis
Objective To assess the clinical efficacy of inhaled nitric oxide (iNO) in the treatment of acute bronchiolitis in infants,focusing on its potential anti-inflammatory and lung function improvement effects. Methods A total of 118 infants with acute bronchiolitis admitted to Huangshi Maternal and Child Health Hospital from January 2016 to December 2023 were included. Patients were randomly divided into a control group and an observation group,with 59 infants in each group. The control group received conventional treatment,and the observation group received iNO combined with conventional treatment. Pulmonary function indices and the expression levels of interleukin-6 (IL-6),C-C motif chemokine ligand 11 (CCL11),and cysteinyl leukot-rienes (CysLTs) in venous blood were measured at admission and after 7 days of treatment. The effects of iNO in the treatment of acute bronchiolitis were analyzed. Results The improvement in lung function in the iNO group was significantly greater than in the control group. The expression levels of inflammatory factors,including IL-6,CCL11,and CysLTs,were significantly lower in the iNO group compared to the control group (P<0.05). Conclusion iNO showed a positive effect in the clinical treatment of acute bronchiolitis. It modulates the immune balance of T cells and inhibits the accumulation of eosinophils in the lungs by reducing their mobilization and migration. This reduces the inflammatory response in lung tissue facilitating the resolution of lung inflammation and reflecting its advantages in lung function improvement.
万方数据
维普
