The Relationship Between PAI-1 and Claudin-18 Levels and the Severity and Prognosis of Respiratory Distress Syndrome
Objective To investigate the relationship between serum PAI-1 and Claudin-18 levels and the severity and prognosis of respiratory distress syndrome (RDS) in preterm infants. Methods A total of 189 preterm infants with RDS treat-ed between January 2022 and March 2024 were included as the observation group. The infants were classified into mild (n=73),moderate (n=62),and severe (n=54) groups based on disease severity. Prognosis outcomes were used to further divide the obser-vation group into a poor prognosis group (n=63,including patients with no improvement,invasive mechanical ventilation,or death) and a good prognosis group (n=126). Additionally,180 healthy preterm infants without RDS served as the control group. Serum PAI-1 and Claudin-18 levels were measured and compared among groups. Correlations between these markers and oxygenation index (OI) were analyzed. Results Serum PAI-1 levels in the observation group were significantly higher than in the control group,whereas Claudin-18 levels were lower (P<0.01). In the moderate and severe groups,serum PAI-1 levels were higher and Claudin-18 levels lower than in the mild group (P<0.01). Similarly,the severe group had higher serum PAI-1 and lower Claudin-18 levels compared to the moderate group (P<0.01). Serum PAI-1 was positively correlated with OI (r=0.741,P<0.001),while Claudin-18 was negatively correlated with OI (r=-0.669,P=0.001). The poor prog-nosis group showed higher PAI-1 and lower Claudin-18 levels compared to the good prognosis group (P<0.05). ROC curve analysis demonstrated that the combination of serum PAI-1 and Claudin-18 levels had higher predictive value for prognosis compared to either marker alone (P<0.05). Conclusion Serum PAI-1 and Claudin-18 levels are closely associated with the severity and prognosis of RDS in preterm in-fants. Their combined measurement provides higher predictive value for prognosis and can serve as a clinical monitoring target.
SerumPAI-1Claudin-18Preterm respiratory distress syndromeSeverity of diseasePrognosis
万方数据
维普
