Study on the Correlation Between PD-1,PD-L1 in Bronchoalveolar Lavage Fluid and Immune Suppression and Prognosis in Patients with Pulmonary Infectious Sepsis
Objective To evaluate the potential of PD-1 and PD-L1 as biomarkers in BALF samples,providing ef-fective indicators of immune suppression and prognosis evaluation in patients with pulmonary infectious sepsis. Methods Eligible patients were enrolled for research and their venous blood and BALF were collected. The expression of PD-1 and PD-L1 in both types of samples,as well as the expression of IL-10 and TNF-α in venous blood,was measured. ROC curves were plotted based on SOFA and APACHE Ⅱ scores to analyze correlations. Results The expression level of IL-10 (P<0.001) in the survival group was higher than that in the death group while the expression of PD-1,PD-L1,and TNF-α (P<0.001) were lower. The SOFA and APACHE Ⅱ scores (P<0.001) of the survival patients were lower than those of the death patients. The de-tection rate of PD-1 and PD-L1 in BALF was higher than that in venous blood. ROC curves demonstrated obvious advantages. Conclusion PD-1 and PD-L1 in BALF samples are valuable as biomarkers for evaluating prognosis.
万方数据
维普
