Effect and Mechanism of Transcranial Magnetic Stimulation Combined with Exercise Training on Motor Function Improvement in Stroke Patients
Objective To explore the clinical application value of transcranial magnetic stimulation (TMS) combined with exercise training in stroke patients. Methods A total of 75 stroke patients received in Yulin Hospital of Traditional Chi-nese Medicine from January 2022 to September 2023 were selected and divided into control group (n=37) and observation group (n=38) according to random number table method. Both groups received conventional drugs and rehabilitation intervention of the affected limb,the control group received exercise training on the basis of this,and the study group received combined TMS inter-vention on the basis of the control group,and both groups were intervened for 4 weeks. Fugl-Meyer Motor Function Rating Scale (FMA),the National Institutes of Health Stroke Scale (NIHSS),evoked potentials[motor evoked potential (MEP),short latency somatosensory evoked potential (SLSEP)]and serum indexes[(nerve growth factor (NGF),myelin basic protein (MBP),Fibu-lin-5)]of the two groups were observed and compared before and after treatment,and the correlation between limb motor function,nerve function,evoked potential and serum index levels was analyzed. Results Compared with before treatment,FMA score,MEP amplitude and serum NGF level in the two groups were significantly increased after 4 weeks of treatment (P<0.05). MEP latency,central motor conduction time (CMCT),SLSEP-related N13-20 peak latency (IPL),NIHSS score,serum MBP and Fibulin-5 levels were significant-ly decreased (P<0.05). After 4 weeks of treatment,MEP amplitude,FMA score and serum NGF level of the study group were significantly higher than those of the control group (P<0.05),MEP latency,CMCT,SLSEP IPL,NIHSS score,serum MBP and Fibulin-5 levels were significantly lower than those of the control group (P<0.05). MEP amplitude and NGF were positively correlated with the total score of FMA (P<0.05),while MEP latency,MEP CMCT,SLSEP N13-20 IPL,MBP,Fibulin-5 were negatively correlated with the total score of FMA (P<0.05). MEP amplitude and NGF were negatively correlated with NIHSS score (P<0.05),while MEP latency,MEP CMCT,SLSEP N13-20 IPL,MBP,Fibulin-5 were positively correlated with NIHSS score (P<0.05). Conclusion TMS combined with motor training can improve the degree of neurological impairment and motor function in stroke patients,and the mechanism may be related to the regulation of evoked potential and the reduction of neuronal injury.
StrokeTranscranial magnetic stimulationSports trainingNerve functionMotor function
万方数据
维普
