Effects of Low Molecular Weight Heparin Anticoagulation on Pulmonary Ventilation,Coagulation Function,Serum NLR,PLR and NSE Levels in Patients with AECOPD
Objective To investigate the effects of LMWH anticoagulation on pulmonary ventilation,coagulation function,serum neutrophil/lymphocyte ratio(NLR),platelet lymphocyte ratio(PLR)and neuron-specific enolase(NSE)levels in AECOPD patients.Methods 65 AECOPD patients admitted to Meishan people's hospital from June 2022 to March 2024 were included into LMWH group(n=33),subcutaneous injection of LMWH based on routine treatment)and routine group(n=32),routine symptomatic treatment,such as oxygen inhalation and anti-infection)by random number table meth-od.The curative effect was evaluated after 1 week of treatment.Pulmonary ventilation,coagulation function,serum NLR,PLR and NSE were measured before and after 1 week of treatment.Results The total effective rate was significantly higher in the LMWH group(93.94%)compared to the routine group(71.88%)After 1 week of treatment,forced expiratory volume,forced vital capacity,peak expiratory flow rate,arterial partial oxygen pressure and oxygen saturation in the two groups in-creased after treatment,and the LMWH group were higher(P＜0.05),while the partial blood pressure of carbon dioxide(PaCO2)was significantly lower(P＜0.05).After 1 week of treatment,the levels of fibrinogen,D-dimer,serum NLR,PLR and NSE in the two groups decreased after treatment,and the LMWH group was lower(P＜0.05),while activated partial thromboplastin time and prothrombin time were significantly longer(P＜0.05).There was no statistically significant difference in adverse reactions between the two groups(P＞0.05).Conclusion LMWH can significantly improve pulmonary ventila-tion and coagulation function,and reduce serum NLR,PLR and NSE levels in AECOPD patients,which is safe and effective.
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