Effect of TACE Combined with SPVE on Serum Tumor Markers and Prog-nosis of Patients with Large Liver Cancer
Objective To investigate the effects of transcatheter arterial chemoembolization(TACE)combined with selective portal vein embolization(SPVE)on serum tumor markers and prognosis of patients undergoing surgery for large liver cancer.Methods A retrospective study was conducted to select 110 patients with large liver cancer who underwent surgery in Meishan second people's hospital from June 2020 to January 2023,and were divided into group A(n=58)and group B(n=52)according to treatment methods.Group A underwent surgery for large liver cancer after TACE and SPVE,group B under-went surgery for large liver cancer after TACE.The residual liver volume,residual liver ratio and serum α-L-fucosidase(AFu),carcinoembryonic antigen(CEA)and alpha-fetoprotein(AFP)levels were compared between the two groups before and after treatment.With the date of admission as the start date of follow-up and June 30,2023 as the end date of follow-up,the long-term survival of the two groups was compared.Cox risk regression model was used to analyze the prognostic factors.Results After treatment,the residual liver volume and residual liver ratio in 2 groups were higher than before treatment,and group A was higher than group B(P＜0.05).AFu,CEA and AFP in 2 groups were lower after treatment than before treat-ment,and group A was lower than group B(P＜0.05).The median survival time of group A was longer than that of group B,the overall survival rate was higher than that of group B,and the average survival time of group A was higher than that of group B(P＜0.05).Cox risk regression analysis suggested that tumor diameter,capsule integrity,degree of differentiation,cirrho-sis,and preoperative TACE+SPVE treatment were the prognostic factors of patients with large liver cancer after surgery(P＜0.05).Conclusion TACE combined with SPVE can more effectively reduce the levels of AFu,CEA and AFP in patients undergoing surgery for large liver cancer,and improve the long-term prognosis.In addition to tumor diameter,capsule integri-ty,degree of differentiation and cirrhosis,preoperative TACE+SPVE treatment is also an influential factor in the prognosis of patients undergoing surgery for large liver cancer.
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