Dynamic Analysis of Heparin-Binding Protein in Acute Pancreatitis and the Correlation between Baseline Heparin-Binding Protein and Patient Progno-sis
Objective To analyze the dynamic changes of heparin-binding protein(HBP)in acute pancreatitis(AP)and the correlation between baseline HBP and patient prognosis.Methods 150 patients with AP treated at department of gas-troenterology,Hebei Qinhuangdao first hospital from December 2021 to December 2023 were included,49 cases showed a poor prognosis(poor prognosis group),and 101 cases showed a good prognosis(good prognosis group).Their HBP levels were measured and their prognosis was recorded.Multivariate logistic regression analysis was performed to analyze the independent risk factors for the prognosis of AP patients,and ROC curve analysis was applied to analyze the predictive value of these risk factors in predicting the prognosis of AP patients.Results The level of HBP in two groups patients decreased gradually dur-ing hospitalization;Multivariate logistic regression analysis showed that high HBP level(OR=2.658),high baseline procalci-tonin(OR=2.771),and high baseline C-reactive protein(OR=1.125)were independent risk factors for the prognosis of AP patients(P＜0.05).ROC curve analysis revealed that the optimal cutoff point for HBP level to predict the prognosis of AP patients is 7.400 ng/mL.Conclusion HBP levels in patients with acute pancreatitis gradually decrease during hospitaliza-tion.Baseline HBP levels are independently associated with the prognosis of patients with acute pancreatitis.The best HBP cut-off point for poor prognosis is 7.400 ng/mL.
国家科技期刊平台
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