Risk Factors for Neonatal Infection and the Clinical Diagnostic Value of Se-rum PCT,IL-6,CRP,and MPV/PLT
Objective To explore the risk factors of neonatal infection and the clinical diagnostic value of serum pro-calcitonin(PCT),interleukin-6(IL-6),C-reactive protein(CRP),and mean platelet volume/platelet(MPV/PLT).Meth-ods This study included 126 cases of neonatal infection admitted to Shanghai Songjiang district maternal and child health hos-pital from January 2022 to March 2024 as the research group(72 cases of mild infection and 54 cases of severe infection),and another 148 non infectious newborns as the control group during the same period.Multivariate logistic regression was ap-plied to analyze the influencing factors of neonatal infections.Receiver operating characteristic(ROC)curves were plotted to analyze the diagnostic value of PCT,IL-6,CRP,and MPV/PLT expression in serum for the degree of neonatal infection before treatment.Results There were statistically prominent differences in gestational age,birth weight,and length of hospital stay between the research group and the control group(P＜0.05).Gestational age and birth weight were protective factors for neo-natal infections(P＜0.05),while length of hospital stay was a risk factor(P＜0.05).Compared with the control group,the levels of serum PCT,IL-6,CRP,and MPV/PLT in the research group were all higher before treatment(P＜0.05).Com-pared with the mild infection group,the severe infection group had higher levels of serum PCT,IL-6,CRP,and MPV/PLT before treatment(P＜0.05).The area under the curve(AUC)for diagnosing severe neonatal infection with serum PCT,IL-6,CRP,and MPV/PLT levels before treatment was 0.706,0.831,0.834,and 0.860,respectively.The AUC for the com-bined diagnosis of the four was 0.951,which was prominently larger than the area under the curve of the individual diagnosis of PCT(Z=4.502,P＜0.01),IL-6(Z=2.855,P=0.004),CRP(Z=2.874,P=0.004),and MPV/PLT(Z=2.336,P=0.019).Conclusion Hospitalization time,gestational age,and birth weight are influencing factors for neonatal infections.Serum PCT,IL-6,CRP,and MPV/PLT levels are all high in infants with neonatal infections,and the combination of the four has high clinical diagnostic value for the degree of infection.
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