The Feasibility of OCTA and Serum VEGF in Evaluating Conbercept in the Treatment of Wet AMD
Objective To explore the feasibility of optical coherence tomography angiography(OCTA)and serum vascular endothelial growth factor(VEGF)in evaluating conbercept in the treatment of wet age-related macular degeneration(AMD).Methods A total of 80 patients with wet AMD admitted to the Ophthalmology Department of Xi'an First Hospital from May 2021 to May 2023 were selected as the study objects,including 49 males and 31 females,all of whom were treated with Conbercept.The therapeutic effect of patients was evaluated after 6 months of treatment,and the best corrected visual a-cuity(BCVA),OCTA and serum indexes were examined before treatment,1 month,3 months and 6 months after treatment.At the same time,the incidence of adverse reactions in patients was evaluated,and the correlation between OCTA and serum indexes and curative effect was analyzed.Results The total effective rate of 80 patients was 88.75%;After treatment,BC-VA and iOP decreased significantly,and BCVA and iOP decreased gradually after 1 month and 3 months of treatment,with statistically significant difference(P＜0.05);After treatment,blood flow density and macular thickness in shallow fovea,macular thickness and choroidal neovascular density in shallow layer of fovea and parafovea decreased significantly,and OCTA index decreased gradually after 3 months and 1 month after treatment(P＜0.05);After treatment,the serum indexes such as transforming growth factor-β1(TGF-β1),VEGF and platelet-derived growth factor(PDGF)significantly decreased,and the serum indexes such as TGF-β1,VEGF and PDGF gradually decreased after 3 months and 1 month after treatment(P＜0.05);The incidence of adverse reactions in 80 patients was 6.25%;Spearman correlation analysis showed that after 6 months of treatment,the blood flow density in shallow fovea,the thickness of macula in shallow layer of fovea and parafovea,and choroidal neovascular density were negatively correlated with the curative effect(r=-0.613,-0.532,-0.547,-0.496,P＜0.05).After 6 months of treatment,TGF-β1,VEGF,PDGF and other serum indexes were negatively correla-ted with the therapeutic effect(r=-0.567,-0.483,-0.672,P＜0.05).Conclusion Conbercept has excellent effica-cy in the treatment of wet AMD,and OCTA and serum VEGF can effectively reflect the changes in the condition of wet AMD treated with Conbercept,providing more effective reference for the evaluation of patients'condition.
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