Changes in Serum HMGB1 and NLRC5 Levels in Pregnant Women with Premature Rupture of Membranes and Their Predictive Value for Histolog-ical Chorioamnionitis
Objective To explore the changes in serum levels of High Mobility Group Box 1(HMGB1)and NOD-like receptor family caspase activation and recruitment domain containing 5(NLRC5)in pregnant women with premature rup-ture of membranes(PROM)and their predictive value for histological chorioamnionitis(HCA).Methods A total of 198 pregnant women with PROM admitted to department of obstetrics and gynecology,Beijing electric power hospital from January 2021 to January 2024 were selected(PROM group)alongside 55 normal pregnant women(control group).Based on the oc-currence of HCA,PROM patients were divided into HCA group(77 cases)and non-HCA group(121 cases).Serum levels of HMGB1 and NLRC5 were measured using enzyme-linked immunosorbent assay(ELISA).Multivariate logistic regression anal-ysis was performed to identify factors associated with HCA in PROM patients,and ROC curve analysis was conducted to evalu-ate the predictive value of serum HMGB1 and NLRC5 levels for HCA in PROM patients.Results Compared with the control group,serum levels of HMGB1 and NLRC5 were significantly elevated in the PROM group(P＜0.05).Prolonged gestational age at PROM was identified as an independent protective factor against HCA,while elevated procalcitonin,C-reactive protein,HMGB1,and NLRC5 were independent risk factors(P＜0.05).The area under the ROC curve for predicting HCA in PROM patients using both HMGB1 and NLRC5 was 0.862,which was higher than the separate predictions of 0.755 and 0.761 for HMGB1 and NLRC5,respectively(P＜0.05).Conclusion Elevated serum levels of HMGB1 and NLRC5 in PROM pa-tients are independent risk factors for the occurrence of HCA,and the combined use of serum HMGB1 and NLRC5 demon-strates high predictive value for HCA in pregnant women with PROM.
Premature rupture of membraneHigh mobility group B1NOD-like receptor family caspase activation and recruitment domain containing 5Histological chorioamnionitisPredictive value
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