Correlation Analysis of Coronary Artery Z Value from Echocardiography,Severity of Disease,and Peripheral Blood CRP and ESR Levels in Children with Kawasaki Disease
Objective To investigate the correlation of coronary artery(CA)Z value from echocardiography,severity of disease,and peripheral blood C-reactive protein(CRP)and erythrocyte sedimentation rate(ESR)levels in children with Kawasaki disease(KD).Methods The clinical data of 67 children with KD who were treated in the Hengshui people,s hos-pital from January 2023 to October 2024 were collected.Children enrolled were divided into the lesion group(n=31)and the non-lesion group(n=36)based on whether CA lesions occurred.All children underwent echocardiography.Their general in-formation and laboratory indicators were collected to analyze factors influencing CA lesions in children with KD.Furthermore,children in the lesion group were grouped based on the inner diameter of the CA.CA diameter,CA Z-value,CRP and ESR levels were compared between the groups.The correlation between Z value and CA diameter,CRP,and ESR was analyzed.Results Univariate analysis and multivariate logistic regression analysis found that elevated CRP,ESR,CA,and CA Z value were independent influencing factors for the occurrence of CA lesions in children with KD(P＜0.05).Children in the lesion group were divided into small group(n=14),medium group(n=10),and giant group(n=7).It was found that CA diam-eter,CRP,ESR,and CA Z value in the small group were lower than those in the medium group.Meanwhile,CA diameter,CRP,ESR,and CA Z value in the medium group were lower than those in the giant group,with statistically significant differ-ences(P＜0.05).Spearman correlation analysis showed that CA Z value was positively correlated with CA diameter,CRP,and ESR in children with KD(P＜0.05).Conclusion CA Z value from echocardiography,CRP,and ESR are independent influencing factors of CA lesions in children with KD.Moreover,CA Z value is closely related to the severity of disease,CRP and ESR levels.It can be used to assist in determining the degree of CA lesions in children with KD.
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