Changes of NK Cell Level in Peripheral Blood of Pregnant Women with Di-abetes and Its Correlation with Insulin Resistance
Objective To analyze the changes of natural killer(NK)cells in the peripheral blood of patients with gestational diabetes(GDM)and their correlation with insulin resistance.Methods 100 GDM patients admitted to our hospi-tal from January 2020 to December 2024 were selected as the study subjects and included in the observation group.Another 40 normal pregnant women who underwent prenatal examinations in our hospital during the same period were selected as the con-trol group.Collect fasting elbow vein blood from the observation group and the control group,compare the expression levels of NK cells between the two groups using flow cytometry,and compare blood glucose and insulin resistance indicators.And Pear-son test was used to analyze the correlation between NK cells and insulin resistance.Results There was no statistically sig-nificant difference(P＞0.05)in general information such as age,body mass index,parity,blood sampling gestational week,delivery gestational week,and delivery method between the observation group and the control group.The fasting blood glu-cose,1-hour postprandial blood glucose,2-hour postprandial blood glucose,glycated hemoglobin,fasting insulin(FINS),and insulin resistance index(HOMA-IR)of the observation group patients were all higher than those of the control group(P＜0.05).The expression levels of NK cells,CD56bright,and CD56dim in the observation group were higher than those in the control group(P＜0.05).According to Pearson test analysis,the expression levels of FINS,HOMA-IR,NK cells,CD56bright,and CD56dim in GDM patients were positively correlated(P＜0.05).Conclusion The number of NK cells and their subsets in the peripheral blood of patients with gestational diabetes is increased,and there is a significant positive correlation between NK cells and insulin resistance,which can participate in the development of gestational diabetes.
Diabetes in pregnancyNatural killer cellsInsulin resistanceCorrelation analysis
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