Effects of Bushen Jiegu Tang Combined with External Application of Medi-cation on Pain and Serum OPG Level in Patients with Acute Swelling after Closed Fracture of Limbs
Objective To observe the effect of Bushen Jiegu Tang combined with external application of medication in treating acute swelling after closed fracture of limbs.Methods A total of 160 patients with acute swelling after closed fracture of limbs admitted to department of orthopedics and traumatology,Foshan hospital of traditional chinese medicine,from July 2022 to February 2024 were gathered and assigned into a control group(apply medication externally on the basis of rehabilita-tion measures such as protecting the affected limb,local immobilization,and raising the affected limb)and a study group(On the basis of the control group,Bushen Jiegu decoction was added)using a digital random table method,with 80 patients in each group.The degree of swelling,degree of pain,hemorheological indicators,inflammatory factors,osteoprotegerin(OPG),transforming growth factor-β1(TGF-β1),fibroblast growth factor-2(FGF-2),and callus growth were compared.Results After 1 week,2 weeks,and 3 weeks of treatment,the degree of swelling,pain,plasma viscosity,hematocrit,tumor necrosis factor-α(TNF-α),interleukin-1,and IL-8 in both groups were lower than before treatment(P＜0.05),and the study group was lower than the control group(P＜0.05);after 2 weeks and 3 weeks of treatment,the degree of swelling,pain,plasma viscosity,hematocrit,TNF-α,IL-1,and IL-8 in both groups were lower than those after 1 week of treatment(P＜0.05),and the study group was lower than the control group(P＜0.05);after 3 weeks of treatment,the degree of swell-ing,pain,plasma viscosity,hematocrit,TNF-α,IL-1,and IL-8 in both groups were lower than those after 2 weeks of treat-ment(P＜0.05),and the study group was lower than the control group(P＜0.05).After 1 week,2 weeks,and 3 weeks of treatment,the OPG,TGF-β1,FGF-2,callus volume score,callus density score,callus margin score,and fracture margin score of both groups were higher than before treatment(P＜0.05),and the study group was higher than the control group(P＜0.05);after 2 weeks and 3 weeks of treatment,the OPG,TGF-β1,FGF-2,callus volume score,callus density score,cal-lus margin score,and fracture margin score of both groups were higher than those after 1 week of treatment(P＜0.05),and the study group was higher than the control group(P＜0.05);after 3 weeks of treatment,the OPG,TGF-β1,FGF-2,callus volume score,callus density score,callus margin score,and fracture margin score of both groups were higher than those after 2 weeks of treatment(P＜0.05),and the study group was higher than the control group(P＜0.05).Conclusion The com-bination of Bushen Jiegu Tang and external application of medication can alleviate swelling and pain,improve hemorheological indicators,regulate TNF-α,IL-1 and IL-8,OPG,TGF-β1 and FGF-2,and promote callus growth in acute swelling after closed fracture of limbs.
Bushen Jiegu TangExternal application of medicationClosed fracture of limbsAcute swellingPain
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