Retrospective Analysis of Risk Factors for Parenteral Nutrition-associated Cholestasis in Extremely and Ultra Premature Infants
Objective To investigate and analyze the risk factors of parenteral nutrition-related cholestasis(PNAC)in very early and ultra-preterm infants.Methods A total of 196 extremely preterm infants(102 cases)and ultra-preterm in-fants(94 cases)who received parenteral nutrition support for more than 14 days were retrospectively analyzed from January 2018 to December 2022.According to whether the subjects had PNAC or not,they were divided into PNAC group and non-PNAC group.The clinical data of the two groups were compared,and the risk factors of PNAC were analyzed by multivariate logistic regression.Results PNAC occurred in 72 of 196 extremely preterm infants and ultra-preterm infants(36.73%).Compared with non-PNAC group,PNAC group had longer hospital stay,parenteral nutrition duration,amino acid,fat milk,glucose use time,PICC and ventilator duration,higher accumulation of amino acid,fat milk,glucose,parenteral nutrition heat card,and higher incidence of sepsis(P＜0.05,P＜0.01).Compared with non-PNAC group,the proportion of probiot-ics used in PNAC group was lower(P＜0.05).Multivariate logistic regression analysis showed that the duration of parenteral nutrition,cumulative dose of parenteral nutrition heat card,sepsis and ventilator duration were risk factors for PNAC in very early and ultra-preterm infants(P＜0.05).Conclusion Prolonged duration of parenteral nutrition and ventilator duration,increased cumulative use of parenteral nutrition heat cards,and combined sepsis increase the risk of PNAC in very early and ultra-preterm infants.Reasonable control of parenteral nutrition support time and prevention of infection are important meas-ures to reduce PNAC in very early and ultra-premature infants.
Parenteral nutritionInfant,prematureCholestasisRisk factorsSepsisCumulative dose of parenter-al nutrition heat cardThe duration of the ventilatorDuration of parenteral nutrition
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