首页|血清SREBP1、AMACR水平对根治性前列腺切除术后患者预后不良的预测效能

血清SREBP1、AMACR水平对根治性前列腺切除术后患者预后不良的预测效能

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  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
目的 探讨血清固醇调节元件结合蛋白1(SREBP1)、α-甲基酰基辅酶A消旋酶(AMACR)水平对根治性前列腺切除术(RP)后患者预后不良的预测效能.方法 选取 2018 年 1 月至 2021 年 7 月行RP的前列腺癌患者142 例(前列腺癌组)和同期来院行健康体检的健康男性71 例(对照组),根据3 年预后将RP患者分为不良组和良好组.采用酶联免疫吸附试验检测前列腺癌组和对照组血清SREBP1、AMACR水平,通过多因素非条件logistic回归分析血清SREBP1、AMACR水平与RP后患者预后不良的关系,采用受试者工作特征(ROC)曲线分析血清 SREBP1、AMACR水平预测RP后患者预后不良的效能.结果 与对照组比较,前列腺癌组血清 SREBP1、AMACR水平升高(P＜0.01).临床分期、前列腺特异性抗原、Gleason评分、SREBP1、AMACR与RP后患者预后不良有关(P＜0.01).多因素非条件logistic回归分析显示,SREBP1 高、AMACR高为RP后患者预后不良的独立危险因素(P＜0.01).ROC曲线分析显示,血清 SREBP1、AMACR 联合预测 RP 后患者预后不良的曲线下面积为 0.868,大于血清 SREBP1、AMACR单独预测的0.782、0.790(P＜0.01).结论 前列腺癌患者血清SREBP1、AMACR水平升高与RP后预后不良密切相关,血清SREBP1、AMACR联合检测预测RP后预后不良有较高的效能.
Efficacy of Serum SREBP1 and AMACR Levels in Predicting Poor Progno-sis after Radical Prostatectomy
Objective To investigate the predictive efficacy of serum sterol regulatory element binding protein 1(SREBP1)and α-methylacyl-CoA racemase(AMACR)levels in patients with poor prognosis after radical prostatectomy(RP).Methods A total of 142 patients with prostate cancer who received RP from January 2018 to July 2021(prostate cancer group)and 71 healthy men who came to our hospital for physical examination during the same period(control group)were selected,and RP patients were divided into poor group and good group according to 3-year prognosis.Serum SREBP1 and AMACR levels in prostate cancer group and control group were detected by enzymed-linked immunosorbent assay.The re-lationship between serum SREBP1 and AMACR levels and poor prognosis after RP was analyzed by multivariate logistic regres-sion.Receiver operating characteristic(ROC)curve was used to analyze the efficacy of serum SREBP1 and AMACR levels in predicting poor prognosis after RP.Results Compared with the control group,the serum levels of SREBP1 and AMACR in prostate cancer group were increased(P＜0.01).Clinical stage,prostate specific antigen,Gleason score,SREBP1 and AMACR were associated with poor prognosis after RP(P＜0.01).Multivariate logistic regression analysis showed that high SREBP1 and AMACR were independent risk factors for poor prognosis after RP(P＜0.01).ROC curve analysis showed that the area under the curve of serum SREBP1 and AMACR combined to predict the poor prognosis of patients with RP was 0.868,which was larger than 0.782 and 0.790 predicted by serum SREBP1 and AMACR alone(P＜0.01).Conclusion The elevated levels of serum SREBP1 and AMACR in prostate cancer patients are closely related to poor prognosis after RP,and the combined detection of serum SREBP1 and AMACR is effective in predicting poor prognosis after RP.

Prostate cancerRadical prostatectomySterol regulatory element binding protein 1α-methylacyl-CoA racemasePrognosisPredictive value

吴鹏、刘强

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226001 江苏 南通,南通市康复医院(南通市第二人民医院)泌尿外科

前列腺肿瘤 根治性前列腺切除术 固醇调节元件结合蛋白1 α-甲基酰基辅酶A消旋酶 预后 预测价值

2024

10.3969/j.issn.2095-3097.2024.08.011

转化医学杂志
海军总医院

转化医学杂志

CSTPCD
影响因子：0.671
ISSN：2095-3097
年,卷(期)：2024.13(8)