A Study on the Correlation Between Epicardial Fat Volume and Coronary Heart Disease Measured by CT Myocardial Perfusion and Coronary CT Angiography
Objective Static CT myocardial perfusion and coronary CT angiography(CCTA)were used to diagnose coronary heart disease(CHD),and epicardial fat volume and its correlation value were measured to study its correlation with CHD.Methods A total of 80 suspected patients diagnosed with coronary artery disease from June 2022 to April 2024 were randomly included.Using coronary artery angiography as the gold standard for the diagnosis of coronary artery disease,the pa-tients were divided into CHD group(n=36)and non-CHD group(n=44).All patients underwent static CT myocardial per-fusion combined with CCTA.Epicardial fat volume,extracardial fat volume and pericardiac total fat volume were measured on the original images.Clinical data and pericardiac fat volume differences between the two groups were analyzed,and independ-ent risk factors of CHD were analyzed by binary Logistic regression model.Spearman correlation coefficient,receiver operating characteristic(ROC)curve analysis,correlation of pericardiac fat volume with CHD and diagnostic efficacy.Results riglyc-eride,low-density lipoprotein,epicardial fat volume and pericardial total fat volume in CHD group were significantly higher than those in non-CHD group(P＜0.05).In the CHD group,there were 19 cases of left anterior descending branch disease,12 cases of left lateral branch disease,and 5 cases of right coronary artery disease;in the non-CHD group,there were 4 cases of left anterior descending branch disease,5 cases of left lateral branch disease,and 1 case of right coronary artery disease.Comparison between the two groups showed that the incidence of various coronary artery abnormalities in the CHD group was significantly higher than that in the non-CHD group(P＜0.05).The area under ROC curve of epicardial fat volume and peri-cardial total fat volume for diagnosing CHD was 0.851 and 0.793,respectively.Epicardial fat volume and pericardial total fat volume were positively correlated with CHD(r=0.510 and 0.428,P＜0.05).Epicardial fat volume and pericardial total fat volume were independent risk factors for CHD(P＜0.05).Conclusion Epicardial adipose tissue volume and pericardial ad-ipose tissue volume are positively correlated with CHD,and are independent risk factors for CHD,which is of great signifi-cance for observing the treatment effect and predicting the prognosis of patients with CHD.
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