Correlation Between Serum GLP-1 and Sirt1 Levels and Bone Mineral Density and Bone Metabolism in Postmenopausal Patients with Osteoporosis
Objective To investigate the correlation between serum glucagon-like peptide 1(GLP-1)and silence-in-formation regulatory factor 1(Sirt1)levels and bone mineral density and bone metabolism in postmenopausal osteoporosis(PMOP)patients.Methods A total of 128 PMOP patients(PMOP group)and 62 healthy volunteers(control group)were selected from January 2021 to May 2023.Serum levels of GLP-1,Sirt1,bone mineral density,and bone metabolism indexes of type I collagen amine-terminal propeptide(PⅠNP),β-collagen degradation products(β-CTX),parathyroid hormone(PTH),osteopontin(OPN),osteocalcin(OC)were detected.Pearson coefficient was used to analyze the correlation be-tween GLP-1,Sirt1 and bone mineral density and bone metabolism.The influence factors of PMOP were analyzed by multiva-riate Logistic regression,and the value of GLP-1 and Sirt1 in the diagnosis of PMOP was analyzed by receiver operating char-acteristics(ROC).Results The menopause age of PMOP group was earlier than that of control group,the number of meno-pause years was longer than that of control group,the body mass index,bone mineral density(lumbar bone mineral density,bilateral femoral neck bone mineral density,total hip bone mineral density),serum PⅠNP,OPN,OC,GLP-1 and Sirt1 lev-els were lower than those of control group,and serum β-CTX,PTH and blood phosphorus levels were higher than those of con-trol group(P＜0.05).Serum GLP-1 and Sirt1 levels in PMOP patients were positively correlated with bone mineral density,PⅠNP,OPN and OC(P＜0.05),and negatively correlated with β-CTX and PTH(P＜0.05).Long menopause years were risk factors for PMOP(P＜0.05),while calcium supplementation,high level of GLP-1 and high level of Sirt1 were protective factors for PMOP(P＜0.05).The area under the curve of PMOP diagnosed by GLP-1 and Sirt1 was 0.789 and 0.779,and the area under the curve of PMOP diagnosed by GLP-1 and Sirt1 combined was 0.908,which was higher than that by single diagnosis(P＜0.05).Conclusion Serum GLP-1 and Sirt1 levels of PMOP are low,which are associated with decreased bone mineral density and abnormal bone metabolism.Combined detection of GLP-1 and Sirt1 levels is helpful to identify the risk of PMOP.
国家科技期刊平台
NSTL
万方数据
