Clinical Characteristics of Different types of Interstitial Lung Diseases com-bined with Lung Cancer
Objective To explore the difference of clinical features of different types of interstitial lung disease(ILD)complicated with lung cancer,and to provide clinical experience.Methods The clinical data of 323 ILD patients ad-mitted to the hospital from January 2018 to December 2020 were retrospectively analyzed,and they were divided into 180 cases of idiopathic pulmonary fibrosis(IPF)group,68 cases of non-IPF group,and 75 cases of connective tissue disease-associated interstitial lung disease(CTD-ILD)group.The incidence and clinical features of lung cancer in 3 combinations were com-pared.The general data of the patients were collected,the clinical symptoms,pathological features and the lesion site of lung cancer were observed,and the clinical features were summarized.Results Compared with pure ILD group,the smoking pro-portion and male proportion in ILD group with lung cancer were higher and the age was older(P＜0.05).Compared with non-IPF group and CTD-ILD group,the incidence of lung cancer was higher in IPF group(P＜0.05).Cough,hemoptysis and dyspnea were the common symptoms of ILD patients with lung cancer in 3 groups.Compared with CTD-ILD group with lung cancer,IPF group with lung cancer and non-IPF group with lung cancer were more prone to dyspnea(P＜0.05).The propor-tion of chronic inflammatory cell infiltration in CTD-ILD patients with lung cancer was higher than that in the other two groups(P＜0.05).Compared with CTD-ILD group with lung cancer,the incidence of fibroplasia in IFP group with lung cancer and non-IFP group with lung cancer was higher(P＜0.05).The incidence of squamous cell carcinoma was the highest among the three groups,followed by adenocarcinoma,but there was no significant difference between the three groups(P＞0.05).The main lesion sites of lung cancer in 3 groups were inferior lobe of lung.Compared with CTD-ILD combined lung cancer group,the proportion of lung cancer lesions in IFP combined lung cancer group and non-IFP combined lung cancer group was higher in ILD lesions(P＜0.05).Conclusion Different types of ILD patients with lung cancer had different clinical manifesta-tions,pathological features and lesion sites.Treatment should be based on the specific conditions of patients to choose the ap-propriate method to improve the quality of life and survival of patients.
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