小胶质细胞在缺血性卒中后脑白质损伤中的作用及针刺干预机制
The role of microglia in white matter injury after ischaemic stroke and the mechanism of acupuncture intervention
高琪 1彭拥军1
作者信息
- 1. 210029 南京中医药大学附属医院针灸康复科
- 折叠
摘要
缺血性卒中后脑白质损伤是导致卒中后长期感觉运动障碍和认知障碍的重要原因,脑白质在卒中后神经恢复中的关键作用不容忽视.目前研究表明小胶质细胞可调控中枢免疫炎症反应,在缺血性卒中诱导的脑白质损伤中起着加重损伤和促进修复的双重作用,而针刺通过调节小胶质细胞达到改善缺血性卒中后脑白质损伤结局的可能干预机制近来颇受关注.其干预机制主要通过抑制Toll样受体 4 信号通路、抑制基质金属蛋白酶-9的表达、促进膜联蛋白 1 和髓细胞触发受体 2 的表达等途径发挥改善炎症环境、促进髓鞘修复与再生的作用.
Abstract
Cerebral white matter injury is a significant contributor to enduring sensorimotor and cognitive impairments post stroke.Microglia are pivotal in modulating immune-inflammatory responses within the central nervous system and play a dual role in both exacerbating injury and facilitating repair in cases of ischaemic stroke-induced white matter injury.This highlights the potential efficacy of acupuncture as a therapeutic intervention target these mechanisms.Recently,the potential mechanism of acupuncture in improving the prognosis of white matter injury post ischemic stroke through the regulation of microglia has attracted much attention.Acupuncture mainly ameliorates the inflammatory milieu and facilitates myelin regeneration and repair by suppressing the TLR4 signaling pathway,reducing MMP-9 expression,and promoting the expression of ANXA1 and TERM2.
关键词
卒中/白质/小神经胶质细胞/针刺Key words
Stroke/White matter/Microglia/Acupuncture引用本文复制引用
基金项目
国家自然科学基金项目(82174484)
国家自然科学基金项目(81973932)
江苏省中医院高峰学术人才项目(k2021rc24)
江苏省第六期"333 高层次人才培养工程"()
出版年
2024
NETL
NSTL
万方数据