99Tcm-奥曲肽显像在肺癌诊断中的应用
99Tcm-octreotide somatostatin receptor imaging in the diagnosis of lung cancer
王秀娟 1任媛 2李险峰 2李思进 2刘建中2
作者信息
- 1. 030001太原,山西省肿瘤医院核医学科
- 2. 030001 太原,山西医科大学第一医院核医学科
- 折叠
摘要
目的 探讨99Tcm-奥曲肽显像对肺癌的临床诊断意义.方法 30例CT检查被怀疑为肺部肿瘤的患者行99Tcm-奥曲肽显像,计算肿瘤病灶和对侧正常肺组织的摄取比值(T/N)并做半定量分析.结果 99Tcm-奥曲肽显像诊断肺癌的灵敏度、特异度和准确度分别为95.7%、71.4%和90.0%.30例患者中,有24例99Tcm-奥曲肽显像为阳性,其中2例为假阳性;6例患者诊断为阴性,其中1例为假阴性.99Tcm-奥曲肽显像共检出阳性病灶46个,其中3个为超声和CT检查未发现的病灶.小细胞肺癌(SCLC)组的T/N(2.78±1.07)明显高于非小细胞肺癌(NSCLC)组(1.75±0.31,t=3.82,P<0.05).结论 99Tcm-奥曲肽显像能够显示肺癌细胞表面的生长抑素受体(SSTR),对肺癌原发灶和转移灶具有一定的诊断价值;99Tcm-奥曲肽显像更有利于SCLC的检测,可作为常规显像方法的一种有效补充.
Abstract
Objective To explore the efficacy of 99Tcm-octrotide somatostatin receptor imaging in the diagnosis of lung cancer. Methods Thirty consecutive patients with pulmonary neoplasms were studied. All lesions detected by scintigraphy were confirmed by histopathology and/or by other imaging modalities. Tumor to non-tumor tissue ratios (T/N) was calculated for semiquantitative analysis. The statistical analysis was carried out using Student t test. Results The sensitivity, specificity and accuracy in differentiating malignant from benign lesion was 95.7%, 71.4% and 90.0%, respectively. Positive image finding was obtained in 24 of 30 patients, and 2 of those was actually false positive on 99Tcm-octrotide imaging. Six patients had negative 99Tcm-octrotide imaging, and one of these was false negative. Forty-six lesions were detected by nuclear imaging, and 3 of these 46 lesions had not been revealed by CT or ultrasound examination. T/N ratio was 2.78±1.07 for SCLC and 1.75±0.31 for NSCLC, respectively(t=3.82,P< 0.05). Conclusion 99Tcm-octreotide somatostatin receptor image can display the distribution of somatostatin receptor in lung cancer. The octreotide uptake rate in small cell lung cancer is significantly higher than in non-small lung cancer, therefore, 99Tca-octreotide image may be more helpful in detecting small cell lung cancer. It can be used as a supplementary diagnostic method to other conventional method.
关键词
肺癌/生长抑素受体/奥曲肽/核素显像Key words
Lung cancer/Somatostatin receptor/Octreotide/Nuclide imaging引用本文复制引用
基金项目
山西省教育厅资助项目(200713049)
出版年
2008
NETL
NSTL
维普
万方数据