间充质干细胞(MSCs)是一类来源于中胚层的成体干细胞，具有自我更新和多向分化的能力。间充质干细胞来源外泌体(MSCs-Exo)是各类MSCs分泌至体液且具有生物活性的细胞外囊泡，具有抗炎、修复、促进细胞增殖和分化、调节毛发生长周期等优势。毛发再生涉及多种细胞及细胞因子的共同作用，其中毛乳头细胞(DPCs)被认为是一种独特的MSCs，具有自体干细胞的功能特性；且作为毛囊的信号中心，在调节毛发生长中发挥重要作用。MSCs-Exo可通过调节毛发生长周期促进DPCs增殖和分化。近年来，MSCs-Exo的研究为毛发再生提供了新策略，该文对相关研究进行了综述，以期对脱发的治疗提供新思路。 Mesenchymal stem cells (MSCs) are a type of adult stem cells derived from the mesoderm, with the ability for self-renewal and multidirectional differentiation. Mesenchymal stem cell-derived exosomes (MSCs-Exo) are bioactive extracellular vesicles secreted by various MSCs into body fluids. They offer advantages such as anti-inflammatory properties, tissue repair, promotion of cell proliferation and differentiation, and regulation of the hair growth cycle. Hair regeneration involves the interaction of various cells and cytokines. Dermal papilla cells (DPCs) are considered as a unique MSCs with the functional properties of autologous stem cells. As the signaling center of the hair follicle, it plays an important role in regulating hair growth. MSCs-Exo can promote the proliferation and differentiation of DPCs by regulating the hair growth cycle. In recent years, research on MSCs-Exo has provided a new strategy for hair regeneration. This article reviewed the research on the use of MSCs-Exo for hair regeneration, aiming to offer new insights for the treatment of alopecia.
Research progress of mesenchymal stem cell-derived exosomes in hair regeneration
Mesenchymal stem cells (MSCs) are a type of adult stem cells derived from the mesoderm, with the ability for self-renewal and multidirectional differentiation. Mesenchymal stem cell-derived exosomes (MSCs-Exo) are bioactive extracellular vesicles secreted by various MSCs into body fluids. They offer advantages such as anti-inflammatory properties, tissue repair, promotion of cell proliferation and differentiation, and regulation of the hair growth cycle. Hair regeneration involves the interaction of various cells and cytokines. Dermal papilla cells (DPCs) are considered as a unique MSCs with the functional properties of autologous stem cells. As the signaling center of the hair follicle, it plays an important role in regulating hair growth. MSCs-Exo can promote the proliferation and differentiation of DPCs by regulating the hair growth cycle. In recent years, research on MSCs-Exo has provided a new strategy for hair regeneration. This article reviewed the research on the use of MSCs-Exo for hair regeneration, aiming to offer new insights for the treatment of alopecia.
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