Application of adipose-derived stem cells in skin graft and skin flap transplantation
高宏 1胡哲源 1结祥 1朱晓海 1李倩 吴镝
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作者信息
1. 海军军医大学长征医院烧伤整形外科，上海 200003
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摘要
皮片移植和皮瓣移植是整形外科应用最广泛的修复重建方式，如何避免移植后皮片和皮瓣的坏死，提高皮片和皮瓣的存活质量一直是整形外科基础与临床研究中的基本问题之一，脂肪来源干细胞(ADSCs)的出现为解决这一问题带来了新的思路。该文从ADSCs的分离、鉴定和生物学特性，ADSCs在皮片移植和皮瓣移植中的应用研究等方面进行综述；同时提出了ADSCs应用中存在的问题，并对其未来进行了展望。 Skin graft and skin flap transplantation are the most widely used reparative and reconstructive method in plastic surgery. How to avoid the necrosis of skin graft and skin flap together with the improvement of survival quality of skin graft and skin flap have always been one of the basic problem in plastic surgery basic and clinical research. The emergence of adipose-derived stem cells has brought a new idea to solve this problem. In this paper, the isolation, identification and biological characteristics of adipose-derived stem cells, application of adipose-derived stem cells in skin graft and skin flap transplantation were reviewed. At the same time, the problems of adipose-derived stem cells and their future prospects were discussed.
Abstract
Skin graft and skin flap transplantation are the most widely used reparative and reconstructive method in plastic surgery. How to avoid the necrosis of skin graft and skin flap together with the improvement of survival quality of skin graft and skin flap have always been one of the basic problem in plastic surgery basic and clinical research. The emergence of adipose-derived stem cells has brought a new idea to solve this problem. In this paper, the isolation, identification and biological characteristics of adipose-derived stem cells, application of adipose-derived stem cells in skin graft and skin flap transplantation were reviewed. At the same time, the problems of adipose-derived stem cells and their future prospects were discussed.
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