Research progress of long non-coding RNA in venous malformations
张昊冉 1林俊杰 1乔军波 1沈志伟 吴镝
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作者信息
1. 郑州大学第三附属医院血管瘤外科 河南省血管瘤与血管畸形重点实验室，郑州 450003
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摘要
长链非编码RNA(lncRNA)是一种主要分布在多种真核生物细胞中的长度大于200个核苷酸的非编码RNA，其本身不能编码蛋白质。静脉畸形作为一类先天性脉管畸形，随着基因测序技术的发展，对其分子发病机制了解日渐深入。lncRNA的异常表达可能与静脉畸形的发生、发展有密切联系。lncRNA可选择性调控血管内皮细胞和血管平滑肌细胞的增殖、凋亡及迁移等，从而影响静脉畸形的发生、发展。lncRNA有望成为静脉畸形一类新的诊断标志物或新的治疗靶点。 Long non-coding RNA(lncRNA) is a kind of non-coding RNA with a length of more than 200 nucleotides mainly distributed in a variety of eukaryotic cells. It cannot encode proteins itself. With the development of gene sequencing technology, the molecular pathogenesis of venous malformation is getting deeper and deeper. Abnormal expression of lncRNA may be closely related to the occurrence and development of venous malformations. LncRNA can selectively regulate the proliferation, apoptosis and migration of endothelial cells and vascular smooth muscle cells, thus the occurrence and development of venous malformations is affected. Therefore, lncRNA is expected to be a novel diagnostic marker or a new therapeutic target for venous malformations.
Abstract
Long non-coding RNA(lncRNA) is a kind of non-coding RNA with a length of more than 200 nucleotides mainly distributed in a variety of eukaryotic cells. It cannot encode proteins itself. With the development of gene sequencing technology, the molecular pathogenesis of venous malformation is getting deeper and deeper. Abnormal expression of lncRNA may be closely related to the occurrence and development of venous malformations. LncRNA can selectively regulate the proliferation, apoptosis and migration of endothelial cells and vascular smooth muscle cells, thus the occurrence and development of venous malformations is affected. Therefore, lncRNA is expected to be a novel diagnostic marker or a new therapeutic target for venous malformations.
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