The effect of sex hormone on adolescent bone growth in patients with disorders of sexual development
刘志婉 1结祥 1张文俊 1刘安堂 2朱鴷 1朱晓海 1胡哲源 1沈志伟 周宇
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作者信息
1. 海军军医大学第二附属医院烧伤、整形外科，上海 200003
2. 上海市第一人民医院整形外科，上海 200080
折叠
摘要
青春期身高的增长受多种因素的影响，其中性激素的作用尤为重要。青春期的身高增长约占成年后最终身高的20%。既往认为由于性激素的紊乱，性发育异常患者的最终身高受损。但性发育异常的分类及亚型较多，不同亚型的性发育异常患者的生长模式也不尽相同。该文就青春期骨骼生长、性激素对青春期骨骼生长的影响、常见性发育异常患者的性激素谱和生长模式以及生长激素的治疗效果进行了阐述。 The growth of puberty height is affected by many factors, among which the role of sex hormones is particularly important. The height increase in puberty accounts for about 20% of the final height in adulthood. It was previously believed that the final height of patients with disorders of sexual development was impaired due to the disorder of sex hormones. However, there are more classifications and subtypes of disorders of sexual development, and the growth patterns of patients with different subtypes of disorders of sexual development are also different. This article briefly reviews puberty bone growth, the effect of sex hormones on puberty bones, the sex hormone spectrum and growth pattern of patients with common disorders of sexual development, and the effect of growth hormone therapy.
Abstract
The growth of puberty height is affected by many factors, among which the role of sex hormones is particularly important. The height increase in puberty accounts for about 20% of the final height in adulthood. It was previously believed that the final height of patients with disorders of sexual development was impaired due to the disorder of sex hormones. However, there are more classifications and subtypes of disorders of sexual development, and the growth patterns of patients with different subtypes of disorders of sexual development are also different. This article briefly reviews puberty bone growth, the effect of sex hormones on puberty bones, the sex hormone spectrum and growth pattern of patients with common disorders of sexual development, and the effect of growth hormone therapy.
关键词
青春期/身高/性激素/性发育异常
Key words
Puberty/Body height/Sex hormone/Disorders of sexual development
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