周围神经损伤是临床常见疾病。传统的治疗方法包括药物治疗、显微外科缝合及自体神经移植等，药物治疗因局部药物浓度所限而治疗效果不佳，外科手段受限于神经缺损长度、自体神经供区有限而影响治疗，且手术治疗仍属于组织层面的修复。随着组织工程和干细胞研究的进展，组织工程结合干细胞的神经再生修复疗法已成为目前的研究热点。该文就周围神经损伤的修复过程、脂肪干细胞在周围神经损伤中的修复机制及近5年来基于脂肪干细胞应用的周围神经损伤后修复的研究进展予以综述。 Peripheral nerve injury is a common clinical disease. Traditional treatments include drug therapy, microsurgery and autologous nerve transplantation. Drug therapy is not effective due to the poor con-centration of local drugs. Surgical method are limited by the length of the nerve defect and the lack of nerve donor sites. In addition, surgery is still tissue repair. With the progress of tissue engineering and stem cell research, tissue engineering combined with stem cells for nerve regeneration and repair has become a current research hotspot. Therefore, this paper reviews the process of peripheral nerve repair after injury, the mechanism and the progress of peripheral nerve repair based on adipose stem cells in the past five years.
Application and progress of adipose-derived stem cells in peripheral nerve injury repair
Peripheral nerve injury is a common clinical disease. Traditional treatments include drug therapy, microsurgery and autologous nerve transplantation. Drug therapy is not effective due to the poor con-centration of local drugs. Surgical method are limited by the length of the nerve defect and the lack of nerve donor sites. In addition, surgery is still tissue repair. With the progress of tissue engineering and stem cell research, tissue engineering combined with stem cells for nerve regeneration and repair has become a current research hotspot. Therefore, this paper reviews the process of peripheral nerve repair after injury, the mechanism and the progress of peripheral nerve repair based on adipose stem cells in the past five years.
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