摘要
在众多的人机不同步类型中，源于呼吸拖带所致的反转触发是一种较为独特的存在，除具有高度的隐匿性之外，如果成功触发呼吸机导致呼吸叠加，将会在控制性机械通气的预期之外提供更大的潮气量和更高的跨肺压，从而引起呼吸机相关肺损伤，并且对膈肌功能也产生一定的影响。本文从流行病学、病理生理学机制、临床意义及分型、识别及干预措施等角度对其研究现状进行综述，旨在提高临床医师的重视程度，并希望以此推动相关临床及基础研究的开展。
Abstract
Among many types of patient-ventilator asynchrony, reverse triggering derived from respiratory entrainment is a unique existence. It's challenging to identify reverse triggering in clinical scenario. What's more, if the ventilator is triggered successfully, it is also called breath stacking. In that case, the increased tidal volume or transpulmonary pressure will lead to ventilator-induced lung injury and influence function of the diaphragm. We have reviewed the epidemiology, pathophysiology mechanisms, phenotypes, clinical significance, and management strategies of reverse triggering, aiming to improve clinical physicians' awareness and facilitate fundamental and clinical research.
基金项目
首都临床诊疗技术研究及转化应用项目(Z201100005520079)
万方数据