摘要
过强的呼吸驱动和呼吸努力可导致肺损伤和膈肌损伤，因此在辅助通气过程中监测呼吸驱动和呼吸努力尤为重要。临床实践中，膈肌电活动和气道阻断压可用来监测呼吸驱动；而食管压和呼气阻断可用来监测呼吸努力。临床上可通过调整呼吸支持力度、镇静剂量和肌松程度来调控适当的呼吸驱动及呼吸努力，以实现肺和膈肌保护性通气策略，防止呼吸机相关肺和膈肌功能损伤。
Abstract
Excessive respiratory drive and effort is associated with lung and diaphragm injury, thus respiratory drive and effort monitoring during mechanical ventilation is especially important. In clinical practice, diaphragm electrical activity and airway occlusion pressure are used to monitor respiratory drive, esophageal pressure and expiratory occlusion are used to monitor respiratory effort. Clinically, appropriate respiratory and effort can be achieved with lung and diaphragm protective ventilation strategy by regulating respiratory support level, adjusting sedative dosages and degree of neuromuscular blockade as to prevent ventilator-induced lung and diaphragm injury.
基金项目
国家自然科学基金(81870066)
江苏省科技厅重点研发(社发)项目(BE2020786)
江苏省医学青年人才项目(QNRC2016807)
江苏省第六期“333高层次人才培养工程”项目()
万方数据