首页|Preparation and properties of poly(ethylene glycol)-b-poly(3-acrylamidophenylboronic acid)glucose responsive particles and their hyaluronic acid-based microneedle patches
Preparation and properties of poly(ethylene glycol)-b-poly(3-acrylamidophenylboronic acid)glucose responsive particles and their hyaluronic acid-based microneedle patches
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To overcome the pain and risk of hypoglycemia in insulin administration,glucose-responsive microneedles have been developed by researchers,which could release insulin according to the blood glucose level.We designed a kind of particles by a reversible addition-fragmentation chain transfer(RAFT)method containing a phenylboronic acid group as the sensor of glucose and carrier of insulin.poly(ethylene glycol)(PEG)-2-(dodecylthio(thiocarbonyl)thio)-2-methylpropionic acid(DDMAT)was synthesized as a macromolecular RAFT agent,which was then reacted with 3-acrylamidophenylboronic acid(AAPBA)to synthesize the block copolymer PEG-b-PAAPBA.Glucose-responsive particles loaded with insulin were prepared by self-assembly based on hydrophilic-hydrophobic interactions.Microneedle patches loaded with glucose-responsive particles were prepared using hyaluronic acid as the substrate.The insulin release behavior of the particles in glucose solutions of 0,100,and 400 mg/dL showed significant glucose responsiveness and good biosafety.The results of blood glucose control experiments in rats indicate that a single microneedle patch can effectively maintain normal blood glucose for over 7 h.
Yichuan HONG、Haojie YU、Li WANG、Xiang CHEN、Di SHEN、Yu WANG、Shuning REN、Yudi HUANG、Jian YANG
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State Key Laboratory of Chemical Engineering,College of Chemical and Biological Engineering,Zhejiang University,Hangzhou 310058,China
Zhejiang-Russia Joint Laboratory of Photo-Electro-Magnetic Functional Materials,College of Chemical and Biological Engineering,Zhejiang University,Hangzhou 310058,China
浙江省自然科学基金Science and Technology Program of Zhejiang Province,China
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