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Time-dependent diffusion magnetic resonance imaging:measurement,modeling,and applications

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Increasingly,attention is being directed towards time-dependent diffusion magnetic resonance imaging(TDDMRI),a method that reveals time-related changes in the diffusional behavior of water molecules in biological tissues,thereby enabling us to probe related microstructure events.With ongoing improvements in hardware and advanced pulse sequences,significant progress has been made in applying TDDMRI to clinical research.The development of accurate mathematical models and computational methods has bolstered theoretical support for TDDMRI and elevated our understanding of molecular diffusion.In this review,we introduce the concept and basic physics of TDDMRI,and then focus on the measurement strategies and modeling approaches in short-and long-diffusion-time domains.Finally,we discuss the challenges in this field,including the requirement for efficient scanning and data processing technologies,the development of more precise models depicting time-dependent molecular diffusion,and critical clinical applications.

Time-dependent diffusionDiffusion magnetic resonance imaging(dMRI)Microstructure imagingMicrostructural model

Ruicheng BA、Liyi KANG、Dan WU

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Key Laboratory for Biomedical Engineering of Ministry of Education,Department of Biomedical Engineering,College of Biomedical Engineering&Instrument Science,Zhejiang University,Hangzhou 310027,China

Ministry of Science and Technology of the People's Republic of ChinaNational Natural Science Foundation of ChinaScience and Technology Department of Zhejiang ProvinceScience and Technology Department of Zhejiang Province

2021ZD0200202821220322020061402022C03057

2024

10.1631/jzus.A2400139

浙江大学学报(英文版)(A辑:应用物理和工程)
浙江大学

浙江大学学报(英文版)(A辑:应用物理和工程)

CSTPCD
影响因子：0.556
ISSN：1673-565X
年,卷(期)：2024.25(10)