扩张型心肌病动物模型及治疗的研究进展
Advances in animal models and treatment of dilated cardiomyopathy
金佳敏 1巩倩 1庄乐南1
作者信息
- 1. 浙江大学动物科学学院,浙江 杭州 310058
- 折叠
摘要
扩张型心肌病(dilated cardiomyopathy,DCM)是一类以一侧或双侧心室扩张和收缩功能障碍为特征的心血管疾病,发病原因包括遗传性的基因突变及多种继发因素.人类DCM动物模型涉及小鼠、大鼠、斑马鱼、猪等多种实验动物,一般通过基因编辑、药物诱导、自身免疫缺陷诱导、病毒感染等方法构建.借助DCM动物模型,研究者对该病的致病机制和治疗靶点进行了深入的研究.本文简述了人类DCM的病理特征、临床症状和流行病学特征,对近年来DCM动物模型的种类和构建方法进行了综述,并对优化造模方法与推动治疗研究提出了新的展望.基于DCM动物模型的治疗研究可以帮助我们更好地理解DCM的发生机制,为开发新的治疗方法提供依据.
Abstract
Dilated cardiomyopathy(DCM)is a cardiovascular disease characterized by one or both ventricular dilation and systolic dysfunction.Its pathogenesis involves inherited genetic mutations and various secondary factors.Human DCM animal models have been developed using a variety of experimental animals such as mice,rats,zebrafish,and pigs,and are generally constructed by gene editing,drug induction,autoimmune deficiency induction,and viral infection.The previous studies have utilized DCM animal models to thoroughly investigate the pathogenic mechanisms and therapeutic targets of this disease.This paper briefly described the pathological features,clinical symptoms,and epidemiological characteristics of human DCM.Furthermore,it reviewed the types of DCM animal models and their construction methods used in recent years.This paper also presented new perspectives on optimizing modeling methods and promoting therapeutic research for DCM.Therapeutic studies based on DCM animal models can help us better understand the mechanisms of DCM and provide a basis for the development of new therapeutic approaches.
关键词
扩张型心肌病/疾病动物模型/生物治疗/基因编辑Key words
dilated cardiomyopathy/animal models of disease/biological therapy/gene editing引用本文复制引用
基金项目
国家重点研发计划项目(2021YFA0805902)
国家自然科学基金项目(32270884)
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据