Advances in animal models and treatment of dilated cardiomyopathy
Dilated cardiomyopathy(DCM)is a cardiovascular disease characterized by one or both ventricular dilation and systolic dysfunction.Its pathogenesis involves inherited genetic mutations and various secondary factors.Human DCM animal models have been developed using a variety of experimental animals such as mice,rats,zebrafish,and pigs,and are generally constructed by gene editing,drug induction,autoimmune deficiency induction,and viral infection.The previous studies have utilized DCM animal models to thoroughly investigate the pathogenic mechanisms and therapeutic targets of this disease.This paper briefly described the pathological features,clinical symptoms,and epidemiological characteristics of human DCM.Furthermore,it reviewed the types of DCM animal models and their construction methods used in recent years.This paper also presented new perspectives on optimizing modeling methods and promoting therapeutic research for DCM.Therapeutic studies based on DCM animal models can help us better understand the mechanisms of DCM and provide a basis for the development of new therapeutic approaches.
dilated cardiomyopathyanimal models of diseasebiological therapygene editing
NETL
NSTL
万方数据
维普
