首页|平阳黄汤茶对小鼠高尿酸血症的影响及其作用机制

平阳黄汤茶对小鼠高尿酸血症的影响及其作用机制

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高尿酸血症会对人体造成严重危害,且近年来发病率越来越高.本研究以平阳黄汤茶为研究对象,探究不同剂量的平阳黄汤茶汤对高尿酸血症小鼠血清尿酸水平的影响及其作用机制.结果表明:不同剂量的平阳黄汤茶汤均可降低高尿酸血症小鼠血清尿酸水平,但不同剂量间无显著差异.通过分析尿酸生成和分解途径发现,不同剂量的平阳黄汤茶汤均能显著抑制肝脏中的黄嘌呤氧化酶活性,从而减少尿酸生成.此外,平阳黄汤可有效改善高尿酸血症小鼠的肾小球、肾小管的病理学特征,同时调节高尿酸血症小鼠肠道菌群组成和结构.推测平阳黄汤可通过保护肾脏及调节肠道菌群来促进高尿酸血症小鼠的尿酸排泄,从而降低血清尿酸水平.本研究为黄茶的功效研究和产品开发以及高尿酸血症的防治提供了一定参考.
Effect of Pingyanghuangtang tea on hyperuricemia in mice and its mechanism
Hyperuricemia can cause serious harm to the human body,and its incidence has been increasing in recent years.In this study,Pingyanghuangtang tea was used to investigate the effects of different dosages of Pingyanghuangtang tea liquor on serum uric acid levels in hyperuricemic mice and its mechanism.The results showed that different dosages of Pingyanghuangtang tea liquor could reduce the serum uric acid levels in hyperuricemic mice,but there were no significant differences between the different dosages.Through the analysis of uric acid production and decomposition pathways,it was found that different dosages of Pingyanghuangtang tea liquor could significantly inhibit the activity of xanthine oxidase in the liver,thereby reducing the production of uric acid.Additionally,Pingyanghuangtang effectively improved the pathological characteristics of the glomerulus and renal tubules in hyperuricemic mice.It also showed that Pingyanghuangtang modulated the composition and structure of the gut microbiota in hyperuricemic mice.It was speculated that Pingyanghuangtang could promote uric acid excretion by protecting the kidney and modulating the gut microbiota of hyperuricemic mice,thereby reducing the serum uric acid level.This study provides some reference for the efficacy research and product development of yellow tea and the prevention and treatment of hyperuricemia.

Pingyanghuangtang teamicehyperuricemiaserum uric acidgut microbiota

楼桢优、周拥军、钟维标、陈韵扬、屠幼英、刘俊生、何普明

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浙江大学农业与生物技术学院茶学系,浙江 杭州 310058

浙江子久文化股份有限公司,浙江 温州 325400

平阳黄汤茶 小鼠 高尿酸血症 血清尿酸 肠道菌群

校企横向项目

校合-2021-KYY-516107-0009

2024

浙江大学学报(农业与生命科学版)
浙江大学

浙江大学学报(农业与生命科学版)

CSTPCD北大核心
影响因子:0.725
ISSN:1008-9209
年,卷(期):2024.50(4)
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