首页|New perspectives on microbiome-dependent gut-brain pathways for the treatment of depression with gastrointestinal symptoms:from bench to bedside

New perspectives on microbiome-dependent gut-brain pathways for the treatment of depression with gastrointestinal symptoms:from bench to bedside

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Patients with depression are more likely to have chronic gastrointestinal(GI)symptoms than the general population,but such symptoms are considered only somatic symptoms of depression and lack special attention.There is a chronic lack of appropriate diagnosis and effective treatment for patients with depression accompanied by GI symptoms,and studying the association between depression and GI disorders(GIDs)is extremely important for clinical management.There is growing evidence that depression is closely related to the microbiota present in the GI tract,and the microbiota-gut-brain axis(MGBA)is creating a new perspective on the association between depression and GIDs.Identifying and treating GIDs would provide a key opportunity to prevent episodes of depression and may also improve the outcome of refractory depression.Current studies on depression and the microbially related gut-brain axis(GBA)lack a focus on GI function.In this review,we combine preclinical and clinical evidence to summarize the roles of the microbially regulated GBA in emotions and GI function,and summarize potential therapeutic strategies to provide a reference for the study of the pathomechanism and treatment of depression in combination with GI symptoms.

DepressionGastrointestinal disordersGut-brain axisPathomechanismTreatment

Menglin LIU、Genhao FAN、Lingkai MENG、Kuo YANG、Huayi LIU

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The First Affiliated Hospital of Henan University of Traditional Chinese Medicine,Brain Disease Regional Diagnosis and Treatment Center,Zhengzhou 450000,China

Tianjin University of Traditional Chinese Medicine,Tianjin 301600,China

The First Affiliated Hospital of Zhengzhou University,Department of Geriatrics,Zhengzhou 450052,China

Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital,Tianjin 300131,China

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2025

10.1631/jzus.B2300343

浙江大学学报(英文版)(B辑:生物医学和生物技术)
浙江大学

浙江大学学报(英文版)(B辑:生物医学和生物技术)

影响因子：0.798
ISSN：1673-1581
年,卷(期)：2025.26(1)