首页|Clinical efficacy and safety of vortioxetine as an adjuvant drug for patients with bipolar depression

Clinical efficacy and safety of vortioxetine as an adjuvant drug for patients with bipolar depression

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Objective:Whether vortioxetine has a utility as an adjuvant drug in the treatment of bipolar depression remains controversial.This study aimed to validate the efficacy and safety of vortioxetine in bipolar depression.Methods:Patients with bipolar Ⅱ depression were enrolled in this prospective,two-center,randomized,12-week pilot trial.The main indicator for assessing treatment effectiveness was a Montgomery-Asberg Depression Rating Scale(MADRS)of≥50%.All eligible patients initially received four weeks of lurasidone monotherapy.Patients who responded well continued to receive this kind of monotherapy.However,no-response patients were randomly assigned to either valproate or vortioxetine treatment for eight weeks.By comprehensively comparing the results of MADRS over a period of 4‒12 weeks,a systematic analysis was conducted to determine whether vortioxetine could be used as an adjuvant drug for treating bipolar depression.Results:Thirty-seven patients responded to lurasidone monotherapy,and 60 patients were randomly assigned to the valproate or vortioxetine group for eight weeks.After two weeks of combined valproate or vortioxetine treatment,the MADRS score in the vortioxetine group was significantly lower than that in the valproate group.There was no difference in the MADRS scores between the two groups at 8 and 12 weeks.The incidence of side effects did not significantly differ between the valproate and vortioxetine groups.Importantly,three patients in the vortioxetine group appeared to switch to mania or hypomania.Conclusions:This study suggested that lurasidone combination with vortioxetine might have potential benefits to bipolar Ⅱ depression in the early stage,while disease progression should be monitored closely for the risk of switching to mania.

Bipolar Ⅱ depressionLurasidoneVortioxetineCombination

Chunxiao DAI、Yaoyang FU、Xuanwei LI、Meihua LIN、Yinbo LI、Xiao LI、Keke HUANG、Chengcheng ZHOU、Jian XIE、Qingwei ZHAO、Shaohua HU

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Department of Psychiatry,the First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China

Department of Clinical Psychology,Hangzhou First People's Hospital,Hangzhou 310006,China

Department of Clinical Pharmacy,the First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China

Fuyang Third People's Hospital,Hangzhou 311402,China

Nanhu Brain-Computer Interface Institute,Hangzhou 311100,China

The Zhejiang Key Laboratory of Precision Psychiatry,Hangzhou 310003,China

School of Brain Science and Brain Medicine,and MOE Frontier Science Center for Brain Science and Brain-Machine Integration,Zhejiang University School of Medicine,Hangzhou 310012,China

Brain Research Institute of Zhejiang University,Hangzhou 310003,China

The S

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2025

10.1631/jzus.B2400470

浙江大学学报(英文版)(B辑:生物医学和生物技术)
浙江大学

浙江大学学报(英文版)(B辑:生物医学和生物技术)

影响因子：0.798
ISSN：1673-1581
年,卷(期)：2025.26(1)