首页|Aberrant network topological structure of sensorimotor superficial white-matter system in major depressive disorder

Aberrant network topological structure of sensorimotor superficial white-matter system in major depressive disorder

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White-matter tracts play a pivotal role in transmitting sensory and motor information,facilitating interhemispheric communication and integrating different brain regions.Meanwhile,sensorimotor disturbance is a common symptom in patients with major depressive disorder(MDD).However,the role of aberrant sensorimotor white-matter system in MDD remains largely unknown.Herein,we investigated the topological structure alterations of white-matter morphological brain networks in 233 MDD patients versus 257 matched healthy controls(HCs)from the DIRECT consortium.White-matter networks were derived from magnetic resonance imaging(MRI)data by combining voxel-based morphometry(VBM)and three-dimensional discrete wavelet transform(3D-DWT)approaches.Support vector machine(SVM)analysis was performed to discriminate MDD patients from HCs.The results indicated that the network topological changes in node degree,node efficiency,and node betweenness were mainly located in the sensorimotor superficial white-matter system in MDD.Using network nodal topological properties as classification features,the SVM model could effectively distinguish MDD patients from HCs.These findings provide new evidence to highlight the importance of the sensorimotor system in brain mechanisms underlying MDD from a new perspective of white-matter morphological network.

Major depressive disorder(MDD)Magnetic resonance imaging(MRI)White matterBrain network

Peng WANG、Yanling BAI、Yang XIAO、Yuhong ZHENG、Li SUN、The DIRECT Consortium、Jinhui WANG、Shaowei XUE

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Center for Cognition and Brain Disorders/Department of Neurology,The Affiliated Hospital of Hangzhou Normal University,Hangzhou 311121,China

Institute of Psychological Science,Hangzhou Normal University,Hangzhou 311121,China

Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments,Hangzhou 311121,China

Jing Hengyi School of Education,Hangzhou Normal University,Hangzhou 311121,China

Institute of Mental Health,Peking University Sixth Hospital,Peking University,Beijing 100191,China

Institute for Brain Research and Rehabilitation,South China Normal University,Guangzhou 510631,China

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2025

10.1631/jzus.B2300880

浙江大学学报(英文版)(B辑:生物医学和生物技术)
浙江大学

浙江大学学报(英文版)(B辑:生物医学和生物技术)

影响因子：0.798
ISSN：1673-1581
年,卷(期)：2025.26(1)