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ATP-binding cassette(ABC)transporters:structures and roles in bacterial pathogenesis

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Adenosine triphosphate(ATP)-binding cassette(ABC)transporter systems are divided into importers and exporters that facilitate the movement of diverse substrate molecules across the lipid bilayer,against the concentration gradient.These transporters comprise two highly conserved nucleotide-binding domains(NBDs)and two transmembrane domains(TMDs).Unlike ABC exporters,prokaryotic ABC importers require an additional substrate-binding protein(SBP)as a recognition site for specific substrate translocation.The discovery of a large number of ABC systems in bacterial pathogens revealed that these transporters are crucial for the establishment of bacterial infections.The existing literature has highlighted the roles of ABC transporters in bacterial growth,pathogenesis,and virulence.These roles include importing essential nutrients required for a variety of cellular processes and exporting outer membrane-associated virulence factors and antimicrobial substances.This review outlines the general structures and classification of ABC systems to provide a comprehensive view of the activities and roles of ABC transporters associated with bacterial virulence and pathogenesis during infection.

ATP-binding cassette(ABC)transporterBacterial pathogenesisVirulence

Shu Sian HOW、Sheila NATHAN、Su Datt LAM、Sylvia CHIENG

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Department of Biological Sciences&Biotechnology,Faculty of Science&Technology,Universiti Kebangsaan Malaysia,43600 UKM Bangi,Selangor,Malaysia

Department of Applied Physics,Faculty of Science&Technology,Universiti Kebangsaan Malaysia,43600 UKM Bangi,Selangor,Malaysia

2025

10.1631/jzus.B2300641

浙江大学学报(英文版)(B辑:生物医学和生物技术)
浙江大学

浙江大学学报(英文版)(B辑:生物医学和生物技术)

影响因子：0.798
ISSN：1673-1581
年,卷(期)：2025.26(1)