Application and prospect of guanidine strong base TBD in organic synthesis
Organic base non-metallic guanidine catalysts have become a hot spot in the field of organic catalysis in recent years.These catalysts offer numerous the advantages,including environmental friendliness,simple preparation,safe operation,affordability and excellent catalytic performance.Among them,1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD),stands out for its ability to activate intermediates by accpeting protons and initiating reactions through the formation of two N—H bonds.Typically,its catalytic performance surpasses that of other guanidine alkaline catalysts.Given these characteristics,TBD holds promising applications in pharmaceutical synthesis,organic chemistry and fine chemical engineering.Accordingly,this review focuses on the organic chemical reactions catalyzed by TBD,summarizing the potential mechanisms behind some reactions.Furthermore,it elucidates the catalytic advantages and future development trends of TBD field.
万方数据
维普
