In view of the problem of high raw material cost and poor selectivity in elimination reaction of the original 16α-hydroxyprednisolone synthesis process,an improved process was developed.The target product 16α-hydroxyprednisolone was synthesized from 21-hydroxypregna-1,4,9(11),16-tetraene-3,20-dione-21-acetate by oxidation,hydroxybromination,debromination and hydrolysis.The production cost and waste emissions were reduced,and the total yield of the reaction reached 82.2%.The structure of product was confirmed by 1H NMR,13C NMR and MS(ESI).The improved synthetic process has the advantages of good selectivity,low cost and high total yield.
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