Prednisone is an drug of adrenal cortex hormone,which is mainly used for the treatment of acute infections and allergic diseases,and has strong anti-inflammatory and anti-allergic effects.This paper summarizes the reported synthetic routes related to prednisone,and makes a preliminary analysis and evalua-tion of each synthetic route,and puts forward the direction of future improvement of the synthesis process of prednisone.By using easily modified steroid compounds as starting materials,using photocatalytic technology to oxidize the 11-position alcohol hydroxyl group,and integrating biological fermentation dehydrogenation,hydroxylation and other technologies,the synthesis process level of prednisone API can be greatly improved.
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