Research Progress of Biological Enzymes in the Synthesis of Chiral Amines
Chiral amine compounds are important pharmaceutical intermediates and important building blocks of a variety of drug molecules,and chiral amine compounds can be prepared by biocatalysis.Biocatal-ysis has the advantages of high efficiency,green and sustainability,and plays an important role in promoting the synthesis of chiral amines and their application in the pharmaceutical field.In this paper,the research progress of amine dehydrogenase and imine reductase in the synthesis of chiral amine compounds is re-viewed,with a focus on the discovery of natural enzymes and the mutational modification of enzymes.In addi-tion,the challenges faced by enzymatic synthesis of chiral amine compounds are summarized,and the future research directions are prospected.
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