Study on Synthesis Process of Arbidol Hydrochloride
Objective:To develop a green,economical and environmentally friendly synthetic route of arbidol hydrochloride.Methods:Arbidol hydrochloride was obtained by using cheap and easily available ethyl acetoacetate as raw material,and was subjected to 6 steps of Nenitzescu reaction,acylation of protective phenol hydroxyl reaction,bromination reaction,phenylthiophenolation reaction,Mannich reaction,and hy-drochloric acid salting reaction.The effects of molar ratio,catalyst,temperature,solvent and other factors on the reaction were investigated,and the purity of intermediates and products was determined by HPLC,and the structure was determined by LC-MS and 1H NMR.Results:The optimized total yield of arbidol hy-drochloride was 44.2%and the HPLC purity was 99.8%.Conclusion:The synthesis route has the advan-tages of easy availability of raw materials,mild conditions and simple operation,which can significantly re-duce production costs and environmental pollution,and is suitable for large-scale industrial production.
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