In order to explore the personalized teaching mode of the smart classroom in colleges and uni-versities,10 key factors affecting the operation effect of the smart classroom in colleges and universities were screened out from the two aspects of classroom environment and teaching aims,and a dynamic learn-ing path was established by means of structural equation model.The result shows that the classroom envi-ronment and teaching aims have a positive influence on the operation effect of the smart classroom,with the influence of the latter bigger than that of the former.It is advisable to emphasize the guiding,motivating,and regulating effects of teaching and design a teaching mode that can meet the individualized development of students.