Objective:Network pharmacology and molecular docking technology combined with TCM dialectical formula were used to explore the weight loss effect and mechanism of tuckahoe sawa diarrhea tablets.Methods:According to the TCM syndrome type and medication experience,the active ingredients and targets of Poringze laxative tablets were collected through TCMSP database and UniProt database.DrugBank,OMIM database and GeneCards database were used to obtain obesity-related targets;The use of venn diagram to obtain the target of poria laxative tablets in the treatment of obesity;The STRING database constructs the target protein interaction network;Using Cytoscape 3.7.2 software to build a"drug-ingredient-key target"network;KEGG enrichment analysis of key targets was carried out by Metescape database.Finally use PyMOL 2.2 and Autodock Tools 1.5.6 software to carry out molecular docking of core targets and core components.Results:After topological analysis,a total of 52 key targets were obtained,and PTGS2 and PPARG may be important targets for the treatment of obesity by poria.In KEGG analysis,Insulin resistance,HIF-1 signaling pathway,PI3K-Akt signaling pathway,and Adipocytokine signaling pathway were closely related to the treatment of obesity.Molecular docking showed good results of quercetin docking with PTGS2 and PPARG,indicating that quercetin may be a key component of tuckahoe sawa diarrhea tablets in the treatment of obesity.Conclusion:tuckahoe sawa diarrhea tablets have the function of slimming in spleen deficiency and obstructive obesity,and realize the function of weight loss through multiple targets and multiple pathways.
tuckahoe sawa diarrhea tabletsnetwork pharmacologymolecular dockingweight loss
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