Objective:To explore the active ingredients and mechanism of action of Paeoniae Radix Alba in the treatment of epilepsy through network pharmacology.Methods:Obtain and screen the active ingredients and targets of Paeoniae Radix Alba from the Encyclopedia of Traditional Chinese Medicine database;Collect epilepsy related genes in GeneCards,OMIM,and DisGeNET databases.After taking the intersection of the active ingredient targets of Paeoniae Radix Alba and epilepsy disease targets,a protein interaction network was constructed using the STRING database.Then,visualization analysis was performed using Cytoscape 3.9.1 software.Core targets were screened using the Centiscape 2.2 plugin,and gene ontology functional annotation(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analysis were performed using the David database,Finally,use Cytoscape 3.9.1 software to construct a drug component target network diagram.Results:There were 158 active ingredient targets in Paeoniae Radix Alba,2398 disease targets in epilepsy,38 intersection genes between Paeoniae Radix Alba and epilepsy,and GO enrichment analysis yielded BP136 entries,CC41 entries,MF49 entries.KEGG analysis revealed 106 pathways.Conclusion:Paeoniae Radix Alba may act on 38 targets such as TNF,Akt1,ALB,and HSP90AA1,inhibiting signaling pathways such as AGE-RAGE and NF kappa B,thereby treating epilepsy in terms of anti-inflammatory effects.
network pharmacologyPaeoniae Radix Albaepilepsyactive ingredientsmechanism of action
国家科技期刊平台
NSTL
万方数据
