To Observe the Effect of Yishen-Buganjiangu Decoction Combined with Ecalcitonin in the Treatment of Primary Osteoporosis and Its Influence on Bone Metabolism and Oxidative Stress
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维普
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目的:探讨益肾补肝健骨方联合依降钙素治疗对原发性骨质疏松症的疗效及对骨代谢及氧化应激的影响.方法:80 例骨质疏松患者分为对照组与观察组,对照组肌内注射依降钙素,10 IU·次-1,2 次·周-1;观察组在对照组基础上加益肾补肝健骨方治疗,两组均治疗 6 个月.比较两组疗效和治疗前后骨密度、骨痛情况[视觉模拟评分(visual analogue scale,VAS)]、骨代谢指标[Ⅰ型前胶原氨基端前肽(procollagen type ⅠN-terminal propeptide,PINP)及Ⅰ型胶原交联C-末端肽(type I C-terminal cross linked peptide,CTX-1)]和血清氧化应激指标[丙二醛(malondialdehyde,MDA)及高级氧化蛋白产物(advanced oxidation protein product,AOPP)].结果:治疗后,观察组总有效率更高(97.50%vs 82.50%,P<0.05),VAS评分更低(P<0.05).治疗后,两组PINP均上升(P<0.05),且观察组更高(P<0.05);两组CTX-1 均下降(P<0.05),且观察组更低(P<0.05).两组不良反应发生率差异不具有统计学意义(P>0.05).结论:益肾补肝健骨方辅助西药治疗原发性骨质疏松症疗效显著,可改善患者骨代谢及氧化应激情况.
Objective:To investigate the effect of Yishen-Buganjiangu decoction combined with ecalcitonin on primary osteoporosis and its influence on bone metabolism and oxidative stress.Methods:Eighty patients with osteoporosis were divided into a control group and an observation group.The control group received intramuscular injection of ecalcitonin,10 IU·time-1,twice a week.The observation group was treated with Yishen Bugan Jiangu decoction on the basis of the control group.Both groups were treated for 6 months.The curative effect,bone mineral density,bone pain[visual analogue scale(VAS)],bone metabolism index[procollagen type Ⅰ N-terminal propeptide(PINP),type I C-terminal cross linked peptide(CTX-1),serum oxidative stress markers[malondialdehyde(MDA)and advanced oxidation protein product(AOPP)]before and after treatment were compared between the two groups.Results:After treatment,the total effective rate of the observation group was higher than that of the control group(97.50%vs 82.50%,P<0.05),and the VAS score was lower than that of the control group(P<0.05).After treatment,PINP increased in the two groups(P<0.05),and it was higher in the observation group(P<0.05).The levels of CTX-1 in the two groups were decreased(P<0.05),and the level in the observation group was lower(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Yishen Bugan Jiangu Decoction combined with western medicine is effective in the treatment of primary osteoporosis,which can improve bone metabolism and oxidative stress.