Objective:To explore the therapeutic effect of ultrasound microbubble-assisted therapy on cerebral ischemia-reperfusion injury in rats.Methods:A rat cerebral ischemia-reperfusion model was prepared by the wire thrombus method.40 successfully modeled rats were randomly divided into a microbubble group(ultrasound irradiation+microbubble+thromb olysis)and a control group(ultrasound irradiation+thrombolysis),with 20 cases in each group.Both groups of rats received treatment at a frequency of 1 times·d-1 for 15 days.At the end of thrombolysis treatment,thrombus clearance scores,severity of neurological damage,and water content of the brain tissue were compared between the two groups.Results:Thrombus clearance score in the microbubble group was higher than that in the control group at 3 and 6 h after grouping(P<0.05).mNSS scores in the microbubble group were lower than that in the control group on the 10th and 15th day after grouping(P<0.05).The water content of brain tissue in the microbubble group was lower than that in the control group on the 8th day after grouping(P<0.05).Conclusion:Ultrasound combined with microbubbles for cerebral ischemia-reperfusion rats contributes to thrombus clearance and is able to attenuate neurological damage and brain tissue water content.
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